Leptospirosis is a bacterial disease that affects humans and animals. It is caused by bacteria of the genus Leptospira. (https://www.cdc.gov/leptospirosis/index.html)
Any pathological or traumatic change in tissue form or function. (FAO, 2009. What You Need to Know about Epizootic Ulcerative Syndrome (EUS) e an Extension Brochure. Food and Agricultural Organization of the UN, Rome. https://www.fao.org/4/i0777e/i0777e.pdf)
Note
Alterations in organisms caused by diseases or external elements